• Site Map
• Contact
• Access

EnglishPage

TAKERORI Hiroshi

Research fields

Our bodies are composed of numerous cells with diverse functions. Even if the cells share their fates, cellular functions in individual cells are differ, depending on their locations within the body, aging, and pathological status, etc. These differences in cellular functions are closely related to cellular energy metabolism. Elucidation of the mechanisms underlying energy production and consumption could lead to the development of tools for drug discovery. To this end, we are studying energy metabolism at both whole body as well as individual cell levels.

We are characterizing phenotypes in SIK (Salt-Inducible Kinase) knock-out mice as animal models with impaired glucose and lipid metabolism. Along with this in vivo analysis, we are developing methods to monitor mitochondrial biogenesis for drug screening systems, which could also provide new measures to evaluate the differentiation status of iPS cells (induced Pluripotent Stem cells) and neuronal activities. In addition, using this knowledge and a library of natural products, we have identified new compounds that regulate cellular functions, such as ｃell differentiation of melanocytes, chondrocytes, and inflammatory cells, thus providing candidates for new materials for cosmetics as well as drugs.

Fig. 1 Dysregulation of cholesterol and bile acid metabolism in SIK3-KO mice	Fig. 2 Metabolic labeling of cellular energy for drug discovery

Research Overview

Research Keywords

Details page

• Researchmap (Researcher database)