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UEDA Hiroshi
Title

Professor
Department Department of Chemistry and Biomolecular Science
Course Biomolecular Science Course

Research fields

Heterotrimeric GTP-binding protein-coupled receptors (GPCRs) have been the target for the discovery of a large number of drugs. My work is focused on understanding the molecular basis of GPCRs-mediated signal transduction.

(1) The study of the cytoskeleton control mechanism through the Rho family GTPase signals by the GPCRs signalling in cell motility.
It is well-known that Rho family small GTPases (Rho GTPases) including RhoA, Rac and Cdc42, regulate the reorganization of actin cytoskeleton. Rho GTPases regulate by Rho GTPases-specific guanine nucleotide exchange factors (RhoGEFs). We have identified several GPCRs signalling-dependent RhoGEFs including FLJ00018 and ARHGEF9. We are currently investigating the regulation mechanisms of their RhoGEFs in cells.
(2) Study of ligand recognition mechanism of olfactory receptors

Heterotrimeric G-protein signalling is likely to play an important role in sensory regulation（e.g., vision and olfaction） in humans and other animals. In humans, there are approximately400types of olfactory GPCRs. We are currently investigating how human olfactory GPCRs recognize fragrant or odorous compounds.

Fig. 1 Effect of RhoGEF expression on cell morphology Fig. 2 Effect of the interacting protein on cell mophology in RhoGEF-transfected cell

Research Overview

Research Keywords

Biological Pharmacy

Functinal Biological Chemistry

Structural Biological Chemisty

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