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TAKI Masayasu

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Our laboratory aims to understand how complex biological phenomena operate at the molecular level and to develop chemical tools that enable their precise manipulation. Building on the fundamental organic synthesis, we design, synthesize, and evaluate novel fluorescent probes that allow us to visualize and analyze the spatiotemporal dynamics of diverse cellular processes. Using these probes, we explore organelle dynamics such as lipid droplets, mitochondria, and the endoplasmic reticulum, as well as the regulatory mechanisms of lipid metabolism, glycan-mediated cell communication, and membrane functional remodeling.

By integrating these molecular tools with advanced fluorescence imaging techniques, including fluorescence lifetime imaging (FLIM) and super-resolution microscopy (SRM), we aim to capture ultra-structures and metabolic states in living cells with high spatiotemporal resolution. These approaches not only deepen our quantitative understanding of cellular functions but also open new avenues for the early detection of diseases and the development of diagnostic and therapeutic technologies.
Guided by the concept of "Visualizing and controlling life through chemistry," our research aspires to build a next-generation platform for probing and manipulating biological functions at the molecular scale.

Fig. 1 Fluorescent probes developed based on rational design strategies	Fig. 2 Fluorescence images captured with our probes

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